Discovery of lipid binding sites in a ligand-gated ion channel by integrating simulations and cryo-EM
Ligand-gated ion channels transduce electrochemical signals converti cap bahama mama in neurons and other excitable cells.Aside from canonical ligands, phospholipids are thought to bind specifically to the transmembrane domain of several ion channels.However, structural details of such lipid contacts remain elusive, partly due to limited resolution